Along with its needed effects, liraglutide (the active ingredient contained in Saxenda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking liraglutide: More common. Bladder pain1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ...7. Wegovy (semaglutide) Wegovy is the newest FDA-approved weight-loss medication and works much the same way as Saxenda, by mimicking the action of the hormone GLP-1 to suppress hunger. Wegovy is a once-a-week injectable. Dosage is increased over the course of several weeks-to-months, until a 2.4 mg dose is achieved.It is used by certain overweight people, such as those who are obese or have weight -related medical problems. Losing weight and keeping it off can lessen the many health risks that come with ...7. Wegovy (semaglutide) Wegovy is the newest FDA-approved weight-loss medication and works much the same way as Saxenda, by mimicking the action of the hormone GLP-1 to suppress hunger. Wegovy is a once-a-week injectable. Dosage is increased over the course of several weeks-to-months, until a 2.4 mg dose is achieved.4. Avoid alcohol. Avoid drinking alcohol while taking Qsymia as it can increase your risk of serious side effects, such as central nervous system depression, and an increase in your risk of falls. 5. Don’t skip meals. Eating regular meals and snacks will help to prevent low blood sugar levels (hypoglycemia). 6. Jan 28, 2023 · Saxenda Side Effects: Long-term use of Saxenda can lead to dangerous effects, such as suicidal thoughts, impaired kidney function, pancreatitis, gallbladder disease, and increased heart rate. Short-Term Diet Pills Side Effects: Due to amphetamine-type effects, medications approved for short-term use can cause elevated heart rate and blood ... The highest dose of Qsymia contains only 15mg of Phentermine, but the average dose of Phentermine (for weight loss when used by itself) is 37.5mg. While it may be nice to have a combination medication, it may actually be better to prescribe both medications individually so you have more control over the dosages of each medication.Jan 11, 2023 · In general, Phentermine chemicals do have side effects on long-term treatment. One of the most common side effects is dry mouth. Aside from this, you may also experience nervousness or jitteriness ... Mar 9, 2020 · However, the EMA has not approved this medication due to its abuse potential, the lack of long-term data on the cardiovascular effects of phentermine, and the cognitive side effects of topiramate—attention, language, and memory impairment . As this drug combination contains phentermine, it is a controlled DEA schedule IV substance. Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech. Tell your healthcare provider if symptoms occur. Slowing of growth. Qsymia may slow the increase in height in children 12 years and older. Increases of acid in bloodstream (metabolic acidosis). 1. Nausea and vomiting. Nausea is the most common semaglutide side effect. Up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials. Nausea is even more common if you’re taking the higher-dose version for weight loss. Vomiting tends to be less common than nausea.Jan 3, 2020 · The Bottom Line. Qsymia is a prescription-only weight loss medication that, when used in conjunction with diet and exercise, has a proven track record in overweight and obese individuals. The most common adverse effects are abnormal skin sensations, dizziness, altered taste, insomnia, constipation, and dry mouth, more severe issues can occur. May 8, 2023 · In clinical studies, patients lost the most weight after taking Contrave for 36 weeks and maintained weight loss through 56 weeks. In terms of phentermine weight loss, studies were only done for a short period of time. Once you stop phentermine, your appetite will return to normal. As a result, weight gain may occur. Phentermine alone or in combination with topiramate is relatively safer. That is why the FDA re-approved the medication for short-term (3-month) weight loss use in 2012. Like other weight-loss drugs, phentermine seeks to complement a healthy lifestyle—not replace it. It is available in 3 formulations (the first 2 of which are phentermine only):Aug 1, 2023 · These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about ... Apr 30, 2014 · This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment. Oct 14, 2022 · In fact, this sort of weight loss is referred to as yo-yo dieting (yes, even if it comes secondary to the use of prescription medication) and can cause some serious long-term problems. #2. Using Phentermine Daily Can and Dose Cause Metabolic Damage. Perhaps the single biggest reason to avoid using Phentermine is that it can cause something ... Feb 14, 2023 · Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Symptoms of severe phentermine side effects include ( 3 , 4 ): Chest pain. Pounding or irregular heartbeat, or fluttering in your chest. Lightheadedness or faintness. Shortness of breath, even with only mild exertion. Swelling in your legs, ankles, or feet (edema) Slurred speech or weakness on one side of your body.Common side effects of phentermine and topiramate may include: joint pain, ankle sprain; flu -like symptoms; dizziness; constipation; numbness or tingly feeling; sleep problems ( insomnia ); dry mouth, changes in your sense of taste; or. mood changes, feelings of low self-worth, loss of interest in things you once enjoyed, thoughts about ...Apr 30, 2014 · This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen. If you are taking any of these drugs: Linezolid or methylene blue. If you are pregnant or may be pregnant. Do not take this drug if you are pregnant. If you are breast-feeding.It is used by certain overweight people, such as those who are obese or have weight -related medical problems. Losing weight and keeping it off can lessen the many health risks that come with ...Common side effects include tingling, dizziness, trouble sleeping, and constipation. Serious side effects may include suicide, abuse. Use is not recommended during pregnancy. Phentermine is a stimulant and appetite suppressant. Topiramate is an anticonvulsant that has weight loss side effects.In clinical studies, phentermine-topiramate reduced body weight by 8.6% to 9.4% more than placebo using a conservative ITT analysis.108. Phentermine-topiramate carries risks of several serious side effects. Notably, topiramate is a recognized teratogen, at least at the higher doses used for the treatment of epilepsy.Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Methods: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months).Approved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ... PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day.weight loss. impaired taste (changes in how things taste) trouble with memory. More common side effects in people taking Topamax for epilepsy include: tingling in the legs and arms. loss of ...Mar 9, 2020 · However, the EMA has not approved this medication due to its abuse potential, the lack of long-term data on the cardiovascular effects of phentermine, and the cognitive side effects of topiramate—attention, language, and memory impairment . As this drug combination contains phentermine, it is a controlled DEA schedule IV substance. Phentermine alone is designed for short-term use only, as there are few long-term studies on its safety. One study observed that people experienced no significant side effects when they took ...Long-term users may also experience unwanted long-term side effects resulting from changes to physiology and neurobiology that accumulate over an extended period of time. Individual Factors Hypothetically, two individuals may commence Qsymia treatment on the same day, at the same dose, and avoid using co-administered substances.What Are Side Effects of Qsymia? Side effects of Qsymia can include: mood changes such as depression, trouble sleeping (insomnia), confusion, dizziness, anxiety, tiredness, irritability, constipation, numbness or tingly feeling, altered sense of taste, dry mouth, unpleasant taste in your mouth, headache, upper respiratory tract infection,Topamax withdrawal can occur when it’s stopped abruptly instead of tapered. The greatest risk is that your seizures worsen. Instead of stopping Topamax at once, your HCP can help you taper your dosage gradually. 7. Gabapentin (Neurontin) Gabapentin (Neurontin) is FDA-approved to treat seizures and nerve pain.Phentermine alone or in combination with topiramate is relatively safer. That is why the FDA re-approved the medication for short-term (3-month) weight loss use in 2012. Like other weight-loss drugs, phentermine seeks to complement a healthy lifestyle—not replace it. It is available in 3 formulations (the first 2 of which are phentermine only):Adults Adverse reactions occurring at greater than or equal to 5% and at least 1.5 times placebo in adults include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth. Adverse reactions reported in greater than or equal to 2% of QSYMIA-treated adults and more frequently than in the placebo group are shown in Table 3. Table 3.The Saxenda Savings Card allows you to pay as little as a $25 copay or save up to $200 per Saxenda prescription. The Savings Card program allows for up to 12 benefits annually. There are eligibility requirements, and other restrictions apply. According to GoodRX, out-of-pocket prices range from $1332.59 to $1432.91.COMMON SIDE EFFECTS OF QSYMIA IN CHILDREN 12 YEARS OLD AND OLDER INCLUDE: Depression, dizziness, joint pain, fever, flu, and ankle sprain. POSSIBLE SIDE EFFECTS OF QSYMIA INCLUDE: Mood changes and trouble sleeping. Qsymia may cause depression or mood problems, and trouble sleeping. Tell your healthcare provider if symptoms occur.Aug 1, 2023 · These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about ... This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Side effects Interactions FAQ What is Qsymia? Qsymia contains a combination of phentermine and topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant.During the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . Since then, anti-obesity drug development process focusses on both weight loss efficacy and cardiovascular safety.Adults Adverse reactions occurring at greater than or equal to 5% and at least 1.5 times placebo in adults include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth. Adverse reactions reported in greater than or equal to 2% of QSYMIA-treated adults and more frequently than in the placebo group are shown in Table 3. Table 3.In clinical studies, patients lost the most weight after taking Contrave for 36 weeks and maintained weight loss through 56 weeks. In terms of phentermine weight loss, studies were only done for a short period of time. Once you stop phentermine, your appetite will return to normal. As a result, weight gain may occur.Feb 14, 2023 · Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ... Feb 14, 2023 · Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Nov 2, 2022 · Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use. trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include: These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about ...Feb 28, 2023 · The Saxenda Savings Card allows you to pay as little as a $25 copay or save up to $200 per Saxenda prescription. The Savings Card program allows for up to 12 benefits annually. There are eligibility requirements, and other restrictions apply. According to GoodRX, out-of-pocket prices range from $1332.59 to $1432.91. What Are Side Effects of Qsymia? Side effects of Qsymia can include: mood changes such as depression, trouble sleeping (insomnia), confusion, dizziness, anxiety, tiredness, irritability, constipation, numbness or tingly feeling, altered sense of taste, dry mouth, unpleasant taste in your mouth, headache, upper respiratory tract infection,Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech. Tell your healthcare provider if symptoms occur. Slowing of growth. Qsymia may slow the increase in height in children 12 years and older. Increases of acid in bloodstream (metabolic acidosis).Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech. Tell your healthcare provider if symptoms occur. Slowing of growth. Qsymia may slow the increase in height in children 12 years and older. Increases of acid in bloodstream (metabolic acidosis).Phentermine Results after 3 Months. First of all, let us clarify if you take Phentermine HCL without any special diet or exercise plan, it is possible to lose around 8 pounds within the 3 months ...Phentermine acts much like a stimulant and has many of the same side effects: increased heart palpitations. increased blood pressure. dizziness. Phentermine is known for being one part of Fen-Phen ...The SELECT trial is the long-term cardiovascular outcomes trial for Wegovy that aims to assess its effects on heart disease and stroke in patients with overweight and obesity; it is currently ongoing and expected to be completed in September 2023. Anti-obesity medication management: An evolving landscapeApproved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ... May 19, 2016 · Long-term users may also experience unwanted long-term side effects resulting from changes to physiology and neurobiology that accumulate over an extended period of time. Individual Factors Hypothetically, two individuals may commence Qsymia treatment on the same day, at the same dose, and avoid using co-administered substances. Phentermine and Qsymia are both medications used for weight loss. Phentermine is only approved for short-term usage, while Qsymia is approved for long-term use. Topiramate is a medication used to treat seizures and prevent migraines. It also happens to have a noticeable weight loss effect, although it’s not approved in Canada solely for ...On July 17, 2012, the FDA approved a tablet combining phentermine plus extended-release topiramate (Qsymia, Vivus) for weight loss. Phentermine has been used for weight loss, and topiramate is an antiepileptic agent that has been commonly associated with weight loss as a side effect. The doses approved for weight reduction are lower than either ... Qsymia works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. When compared to Contrave, researchers found that Qsymia is usually the more effective option. 3.Aug 22, 2021 · Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ... The FDA lists its typical side effects as possibly including nausea, dry mouth, diarrhea, GERD, and dry eye. 1 REPLY Updated December 26, 2021. Qsymia side effects after break. I was on Qsymia for about 16 months with no side effects. I lost 40 pounds at that time.Common side effects of Qsymia include: constipation, insomnia, nasopharyngitis, paresthesia, mood disorder, sleep disorder, and xerostomia. Other side effects include: urinary tract infection, anxiety, blurred vision, depression, dizziness, fatigue, influenza, nausea, increased serum creatinine, and dysgeusia.Side Effects of Qsymia. Side effects of Qsymia in patients taking it for up to one year were paraesthesia (tingling or pins-and-needles sensations most often in the hands, feet, or face), dizziness, dysgeusia (distortion of the sense of taste), insomnia, constipation, and dry mouth. This medication can cause a mild (2 bpm) increase in resting ...Qsymia works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. When compared to Contrave, researchers found that Qsymia is usually the more effective option. 3.Apr 8, 2013 · PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day. Along with its needed effects, liraglutide (the active ingredient contained in Saxenda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking liraglutide: More common. Bladder painCOMMON SIDE EFFECTS OF QSYMIA IN CHILDREN 12 YEARS OLD AND OLDER INCLUDE: Depression, dizziness, joint pain, fever, flu, and ankle sprain. POSSIBLE SIDE EFFECTS OF QSYMIA INCLUDE: Mood changes and trouble sleeping. Qsymia may cause depression or mood problems, and trouble sleeping. Tell your healthcare provider if symptoms occur.May 15, 2023 · On the positive side, lower doses of semaglutide, the active ingredient in Wegovy, have been used to treat diabetes for several years now, though UpToDate, a site that aggregates research about treatments to support decision-making by physicians, notes that there have been very few trials lasting more than four years, so the long-term safety of ... Feb 14, 2023 · Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Phentermine is approved for long-term use (>12 weeks) for weight management in combination with topiramate (Qsymia). Phentermine alone continues to be approved for short-term use (e.g., 12 weeks). In reality, phentermine is prescribed off-label to patients for longer than 12 weeks, and a recent study found improved weight loss and no adverse ...Side effects Interactions FAQ What is Qsymia? Qsymia contains a combination of phentermine and topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant.Phentermine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phentermine belongs to the group of medicines known as appetite suppressants. This medicine is available only with your doctor's prescription.Jun 17, 2022 · The options have short-term side effects and long-term risks. However, when other weight loss medications and diets have not produced adequate results, doctors may consider surgery. 7. Wegovy (semaglutide) Wegovy is the newest FDA-approved weight-loss medication and works much the same way as Saxenda, by mimicking the action of the hormone GLP-1 to suppress hunger. Wegovy is a once-a-week injectable. Dosage is increased over the course of several weeks-to-months, until a 2.4 mg dose is achieved.Side effects Interactions FAQ What is Qsymia? Qsymia contains a combination of phentermine and topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant.May 19, 2016 · Long-term users may also experience unwanted long-term side effects resulting from changes to physiology and neurobiology that accumulate over an extended period of time. Individual Factors Hypothetically, two individuals may commence Qsymia treatment on the same day, at the same dose, and avoid using co-administered substances. May 15, 2023 · On the positive side, lower doses of semaglutide, the active ingredient in Wegovy, have been used to treat diabetes for several years now, though UpToDate, a site that aggregates research about treatments to support decision-making by physicians, notes that there have been very few trials lasting more than four years, so the long-term safety of ... Qsymia side effects can include trouble sleeping if taken in the evening and potential seizures if you stop the medication abruptly. Other side effects can include dizziness, drowsiness, dry mouth, tiredness, tingling of the hands/feet, constipation, and metallic tastes. Some of the more serious side effects can include temporary difficulty ...
As long as you are not taking the medication continuously with no breaks, and will stop the medication eventually, I believe that this is a safe treatment for you. That being said, you mentioned 5 years in the beginning of the question. If you have been taking the medication 3 months on, 1 month off for 5 years, I would consider that long term .... Oupv captains license
Phentermine has the advantage of low cost and many years of clinical experience, but its long-term use is considered off-label, long-term effects on CVD outcomes are unknown, and most use has been a few months or less. 41 There are even fewer data for long-term safety and efficacy of the other noradrenergic agents. Orlistat has a reasonably ...Jan 12, 2023 · Qsymia works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. When compared to Contrave, researchers found that Qsymia is usually the more effective option. 3. On July 17, 2012, the FDA approved a tablet combining phentermine plus extended-release topiramate (Qsymia, Vivus) for weight loss. Phentermine has been used for weight loss, and topiramate is an antiepileptic agent that has been commonly associated with weight loss as a side effect. The doses approved for weight reduction are lower than either ... May 19, 2016 · Long-term users may also experience unwanted long-term side effects resulting from changes to physiology and neurobiology that accumulate over an extended period of time. Individual Factors Hypothetically, two individuals may commence Qsymia treatment on the same day, at the same dose, and avoid using co-administered substances. The SELECT trial is the long-term cardiovascular outcomes trial for Wegovy that aims to assess its effects on heart disease and stroke in patients with overweight and obesity; it is currently ongoing and expected to be completed in September 2023. Anti-obesity medication management: An evolving landscapeor short-term obesity treatment in conjunction with lifestyle modifications, but is commonly used chronically. Topiramate, approved for treating epilepsy and preventing migraines, also induces weight loss. A single-dose combination of low-dose phentermine and topiramate extended-release was recently approved by the United States Food and Drug Administration as an adjunct to lifestyle ...Phentermine-Topiramate Capsule, Extended Release Multiphase 24 Hr (Capsule, ER Hr) - Uses, Side Effects, and More Common Brand(S): Qsymia Generic Name(S): phentermine-topiramate Feb 14, 2023 · Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ... Ozempic, a medication used in type 2 diabetes, is currently under review by the FDA to be approved for weight loss in overweight or obese adults. Phentermine may be a more accessible option to help you lose weight, but it should only be used for a few weeks. Both Ozempic and phentermine can help to curb your appetite so that you eat fewer ...Topamax dosage for migraines. For people ages 12 and older, the recommended total daily dose for preventing migraines is 100 mg per day, divided into two doses. 6. Topamax can be prescribed for weight loss. Generic Topamax (topiramate) is used in combination with phentermine in a weight loss medication called Qsymia.Qsymia's results have been clinically tested in two long-term studies with ... QSYMIA CAN CAUSE SERIOUS SIDE EFFECTS, INCLUDING: Birth defects (cleft lip/cleft palate). If you take Qsymia during ... From research studies, an outline of the common and rare side effects associated with Qsymia is as follows: Common side effects (reported in more than 1% of patients): Paresthesia (tingling, numbness) of the extremities (15-38%) Dizziness (11-28%) Dysgeusia (abnormal taste sensation) (6-19%) Insomnia (7-17%) Constipation (6-16%)May 8, 2023 · In clinical studies, patients lost the most weight after taking Contrave for 36 weeks and maintained weight loss through 56 weeks. In terms of phentermine weight loss, studies were only done for a short period of time. Once you stop phentermine, your appetite will return to normal. As a result, weight gain may occur. Qsymia is prescription-only weight loss medication that contains a combination of phentermine HCl and topiramate extended-release. This drug, which received FDA approval in 2012, helps manage obesity longer-term than phentermine alone, but also carries the risk of additional side effects (1, 2).Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes /nose/throat, cough, runny ... However, the EMA has not approved this medication due to its abuse potential, the lack of long-term data on the cardiovascular effects of phentermine, and the cognitive side effects of topiramate—attention, language, and memory impairment . As this drug combination contains phentermine, it is a controlled DEA schedule IV substance..